By Günther Jung
The tale of good fortune is going on and on - with a brand new ebook on combinatorial chemistry, edited via Gunther Jung!
Combinatorial chemistry is a confirmed time- and resource-saving man made approach to awesome value for commercial techniques. Compound libraries aid to save lots of money and time, in particular within the look for new medications, and for this reason play a pivotal position in fixing the matter of the global expanding call for for brand spanking new and extra lively medicinal drugs. not just components, that are of curiosity for pharmaceutical chemistry, but in addition fabrics, catalysts, and biomolecules reminiscent of DNA or oligosaccharides are available with excessive structural diversities. The wide scope of combinatorial sciences is mirrored through this ebook, edited through Gunther Jung: the unreal tools mentioned diversity from solid-phase to solution-phase synthesis, from arrangements of small molecules reminiscent of amines or alcohols to these of advanced biomolecules. possible equipment, effective options, new developments in automation, and cutting-edge quick instrumental analytical and screening tools are provided with many useful assistance and tips for everyone operating in combinatorial chemistry.
this can be the e-book written by means of experts for experts and for everybody desiring to turn into an insider! it truly is an indispensible resource of data for researchers operating in natural synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and medical chemistry, fabric sciences, and analytical chemistry.
Chapter 1 Combinatorial Chemistry (pages 1–34): Dominika Tiebes
Chapter 2 Survey of Solid?Phase natural Reactions (pages 35–76): Susan E. sales space, C. Marijke Dreef?Tromp, Petro H. H. Hermkens, Jos A. P. A. de guy and Harry C. J. Ottenheijm
Chapter three Solution?Phase Combinatorial Chemistry (pages 77–123): Volkhard Austel
Chapter four Combinatorial Chemistry of Multicomponent Reactions (pages 125–165): Ivar Ugi, Alexander Domling and Birgit Ebert
Chapter five Solid?Phase Anchors in natural Chemistry (pages 166–228): Ralf Warrass
Chapter 6 using Templates in Combinatorial Chemistry for the Solid?Phase Synthesis of a number of middle constitution Libraries (pages 229–256): Hartmut Richter, Axel W. Trautwein and Gunther Jung
Chapter 7 Combinatorial man made Oligomers (pages 257–290): Alberto Bianco
Chapter eight Glycopeptide and Oligosaccharide Libraries (pages 291–318): Phaedria M. St. Hilaire and Morten Meldal
Chapter nine RNA and DNA Aptamers (pages 319–333): Michael Famulok
Chapter 10 Combinatorial methods to Molecular Receptors for Chemosensors (pages 334–353): Dietmar Leipert, Jurgen Mack, Rolf Tunnemann and Gunther Jung
Chapter eleven Peptide Libraries in T?Cell?Mediated Immune reaction (pages 355–380): B. Fleckenstein, G. Jung and K.?H. Wiesmuller
Chapter 12 Combinatorial Biosynthesis of Microbial Metabolites (pages 381–407): Andreas Bechthold and Jose Antonio Salas Fernandez
Chapter thirteen layout and variety research of Compound Libraries for Lead Discovery (pages 409–439): Hans subject and Matthias Rarey
Chapter 14 tips to Scale?up whereas thinning out: EVOscreen™, a Miniaturized Ultra?High?Throughput Screening procedure (pages 440–461): Rodney Turner, Sylvia Sterrer, Karl?Heinz Wiesmuller and Franz?Josef Meyer?Almes
Chapter 15 High?Throughput Experimentation in Catalysis (pages 463–477): Ferdi Schuth, Christian Hoffmann, Anke Wolf, Stephan Schunk, Wolfram Stichert and Armin Brenner
Chapter sixteen FT?Infrared Spectroscopy and IR?Microscopy On?Bead research of Solid?Phase Synthesis (pages 479–498): Holger Bandel, Wolfgang Haap and Gunther Jung
Chapter 17 Mass Spectrometric research of Combinatorially Generated Compounds and Libraries (pages 499–532): Roderich Su?muth, Axel Trautwein, Hartmut Richter, Graeme Nicholson and Gunther Jung
Chapter 18 High?Resolution Magic perspective Spinning (MAS) NMR Spectroscopy for On?Bead research of Solid?Phase Synthesis (pages 533–542): Ralf Warrass and man Lippens
Chapter 19 automatic Combinatorial Chemistry (pages 543–559): Martin iciness, Karl?Heinz Wiesmuller and Gunther Jung
Chapter 20 Fourier rework Ion Cyclotron Resonance Mass Spectrometry (FT?ICR?MS) for research of Compound Libraries (pages 561–581): Tilmann B. stroll, Axel W. Trautwein, Holger Bandel and Gunther Jung